Clinical Comparison of Tubocurarine and Pancuronium
نویسندگان
چکیده
منابع مشابه
A clinical comparison of pancuronium bromide with D-tubocurarine in adult Nigerian patients.
PA~CU~ONrOM B~OMIDE (Organon NA97) is a steroid compound non-depolarizing neuromuscular blocking agent, 1 synthesized by Hewett and Savage in 1964. Following extensive pharmacological studies in animals, Buckett and Bonta 2 suggested that this agent possessed properties similar to those of d-tubocurarine but with certain differences in side effects. Its potency is claimed to be about five times...
متن کاملComparison of speed of onset of fazadinium, pancuronium, tubocurarine and suxamethonium.
Under light general anaesthesia the speed of onset of action of fazadinium, pancuronium, tubocurarine and suxamethonium has been assessed by measuring the decrease in the twitch height of the adductor pollicis muscle following administration of the drugs. Suxamethonium produced 95% depression of the twitch height significantly faster than any of the other drugs, while the onset of fazadinium wa...
متن کاملEffects of general anaesthesia on the intraocular pressure in man. Comparison of tubocurarine and pancuronium in nitrous oxide and oxygen.
The introduction of new anaesthetic drugs demands that their action should be compared with that of already established agents. Pancuronium bromide was introduced into clinical anaesthetic practice by Baird and Reid (I967), and has since achieved widespread acceptance because it is reputed to have fewer cardiovascular side-effects than other non-depolarizing relaxants (Baird, I968; Sellick, 197...
متن کاملThe kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium.
Equilibrium conditions of neurotransmitter concentration and receptor binding are never achieved during synaptic transmission at the neuromuscular junction. Thus, it is important to determine the binding kinetics of drugs that act this synapse. Previous determinations of the dissociation rate of (+)-tubocurarine have produced inconsistent results ranging from 0.1 to 4000/s. Here, we used a dire...
متن کاملFade characteristics and onset times following administration of pancuronium, tubocurarine and a mixture of both agents.
The onset characteristics of pancuronium, tubocurarine and a mixture of these two neuromuscular blocking drugs were studied during the induction of neuromuscular blockade, using a train-of-four pattern of stimulation. Four characteristics of onset were defined: train-of-four fade = a reduction in the height of the fourth twitch greater than a reduction in the height of the first twitch; latent ...
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ژورنال
عنوان ژورنال: Anaesthesia and Intensive Care
سال: 1972
ISSN: 0310-057X,1448-0271
DOI: 10.1177/0310057x7200100111